HiSORセミナー
Overview of Past & Current Scientific Researches for Prominent Future Studies at HiSOR
日時 2021年11月9日 （火） 16：20～17：30頃
場所 オンライン(Zoom形式)
講師 Mohamed Ibrahim
(HiSOR)
Organic and Polymer Chemistry fields are fascinating disciplines since they are involved in designing promising candidates for several applications (medicine, environment, industry, agriculture, etc.). In previous studies, our organic group could synthesize a number of modified linear and cyclic pseudopeptides [e.g., (D-Phe-azaPhe-Ala)2], to investigate their conformations & self-assembly with the possibility of gel formation [1, 2]. On the other side, our polymer chemistry targeted the synthesis of thermo-responsive poly(AAm-co-AN)copolymers through photo-RAFT polymerization, reporting the phase transition of the system with the upper critical solution temperatures (UCST) as a function of polymer concentrations. [3]. In a separate study, our collaborator at the Egyptian Atomic Energy Authority has established a simple and efficient separation method of carrier-free 47Sc from neutron irradiated titanium target using a novel chitosan-acrylic acid/multiwalled carbon nanotubes (CS-AA/MWCNTs) composite. The composite depicted a selective adsorption of Sc(III) rather than Ti(IV) ions with adsorption efficiency of ~ 93.93% [4]. Recently, biopolymers have gained much interest competing those of petroleum origin [5, 6]. In the previous work, our microbiology team could produce exopolysaccharide by Aspergillus terreus (isolated from marine sediment), possessing anticoagulant and cytotoxic activities against breast cancer and human skin fibroblast cell lines (IC50 > 100 mg/mL and IC50 ~ 47 mg/mL), respectively [7].
The structure characterization and identification of molecules are usually established using complement techniques e.g., NMR, IR, SEC, SEM, EDX, UV-Vis, etc. Numerous studies reported promising applications of several biomolecules, rare studies went deep for their structural elucidation using other advanced physical facilities such as Circular-Dichroism spectroscopy (SRCD) [8-10]. In this context, there is a good opportunity of using SRCD for providing more detailed information of molecules’ structures for better understanding their mechanisms of action in biological systems [11].
[1] Ibrahim, M.I.A., Z. Zhou Zhou, C. Cheng Deng, C. Didierjean, R. Vanderesse, J. Bodiguel, M.-C. Averlant-Petit and B. Jamart-Grégoire. 2017 Eur. J. Org. Chem. 4703–4712.
[2] Ibrahim, M.I.A., G. Pickaert, L. Stefan, B. Jamart-Grégoire, J. Bodiguel and M.-C. Averlant-Petit. 2020 RSC Adv. 10(71) 43859-43869.
[3] Lertturongchai, P., M.I.A. Ibrahim, A. Durand, P. Sunintaboon and K. Ferji. 2020 Macromol. Rapid Commun. 41(9) 2000058.
[4] Gizawy, M.A., H.A. Shamsel-Din, I.M. Abdelmonem, M.I.A. Ibrahim, L.A. Mohamed and E. Metwally. 2020 Int. J. Biol. Macromol. 163 79-86.
[5] Babu, R.P., K. O'Connor and R. Seeram. 2013 Prog. Biomater. 2(1) 8.
[6] Morelli, A., M. Betti, D. Puppi and F. Chiellini. 2016 Carbohydr. Polym. 136 1108-17.
[7] Saleh Amer, M., E.H. Zaghloul and M.I.A. Ibrahim. 2020 Egypt. J. Aquat. Res. 46(4) 363-369.
[8] Demain, A.L., E. Vandamme, J. Collins and Z. BuchhoI, History of industrial biotechnology, In: Industrial Biotechnology: Microorganisms, ed. C. Wittmann and J.C. Liao. 2017: Wiley-VCH, Weinheim. pp. 1–84.
[9] Pham, J.V., M.A. Yilma, A. Feliz, M.T. Majid, N. Maffetone, J.R. Walker, E. Kim, H.J. Cho, J.M. Reynolds, M.C. Song, S.R. Park and Y.J. Yoon. 2019. 10(1404).
[10] Rogers, K. 2020 Biomolecule Encyclopedia Britannica, https://www.britannica.com/science/biomolecule.
[11] Matsuo, K. and K. Gekko, In: Lipid-Protein Interactions. Circular-Dichroism and Synchrotron-Radiation Circular-Dichroism Spectroscopy as Tools to Monitor Protein Structure in a Lipid Environment, ed. K. J. 2019, Methods in Molecular Biology, vol 2003. Humana, New York, NY.
問合せ先 松尾光一、出田真一郎（放射光科学研究センター）
